SCHEMBL7313868

SCHEMBL7313868

O=C(O)C(Cc1csc2ccccc12)C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.59
TAAR1 Q96RJ0 1/20 0.51
POLB P06746 1/20 0.49
SMN1; SMN2 Q16637 4/20 0.47
TP53 P04637 2/20 0.47
RXFP1 Q9HBX9 1/20 0.47
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CTSL P07711 1/20 0.46
CTSS P25774 1/20 0.46
CTSK P43235 1/20 0.46
KMT2A Q03164 1/20 0.46
CMA1 P23946 1/20 0.46
HDAC6 Q9UBN7 2/20 0.46
FAAH O00519 1/20 0.45
HDAC1 Q13547 1/20 0.45
MTNR1A P48039 1/20 0.45
DPP4 P27487 1/20 0.44
DPP8 Q6V1X1 1/20 0.44
DPP9 Q86TI2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8481116 0.88 CYP2A6 (0.58) CYP2A6TAAR1POLBSMN1; SMN2TP53
SCHEMBL8486771 0.87 CYP2A6 (0.49) CYP2A6TAAR1POLBSMN1; SMN2TP53
SCHEMBL8432969 0.85 CYP2A6 (0.54) CYP2A6TAAR1POLBSMN1; SMN2TP53
SCHEMBL514508 0.85 CYP2A6 (0.54) CYP2A6TAAR1POLBSMN1; SMN2TP53
SCHEMBL29373380 0.85 CYP2A6 (0.54) CYP2A6TAAR1POLBSMN1; SMN2TP53
SCHEMBL514509 0.85 CYP2A6 (0.54) CYP2A6TAAR1POLBSMN1; SMN2TP53
SCHEMBL1421072 0.85 CYP2A6 (0.54) CYP2A6TAAR1POLBSMN1; SMN2TP53
SCHEMBL14947066 0.85 CYP2A6 (0.54) CYP2A6TAAR1POLBSMN1; SMN2TP53
SCHEMBL21309831 0.85 CYP2A6 (0.54) CYP2A6TAAR1POLBSMN1; SMN2TP53
SCHEMBL2466886 0.85 CYP2A6 (0.54) CYP2A6TAAR1POLBSMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5459131-A Renin inhibitors AMERICAN CYANAMID COMPANY (US) 1995-10-17 US disclosed