Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7309472 | 0.84 | CHRM1 (0.52) | OPRK1CHRM1 | |
| SCHEMBL11352761 | 0.83 | OPRK1 (0.42) | OPRK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL7304407 | 0.82 | OPRK1 (0.46) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL7319992 | 0.80 | OPRK1 (0.43) | OPRK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL10963938 | 0.78 | OPRK1 (0.41) | OPRK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL7310525 | 0.77 | OPRK1 (0.38) | OPRK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL10963912 | 0.74 | OPRK1 (0.79) | OPRK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL27390735 | 0.74 | GABRA1 (0.50) | OPRK1GABRA1GABRG2GABRB3GABRA5 | |
| Maleic Acid SCHEMBL7408000 | 0.73 | OPRK1 (0.44) | OPRK1 | |
| Bromide SCHEMBL8612373 | 0.73 | GABRA1 (0.49) | OPRK1GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0054839-B1 | 2-ACYLAMINOMETHYL-1,4-BENZODIAZEPINES AND THEIR SALTS, METHODS OF PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Kali-Chemie Pharma GmbH (DE) | 1985-06-19 | — | — | EP | disclosed |
| US-4440685-A | MUSCLE RELAXANTS, SEDATIVES, ANTICONVULSANTS | HOFFMANN-LA ROCHE INC. (US) | 1984-04-03 | — | — | US | disclosed |
| US-4425272-A | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1984-01-10 | — | — | US | disclosed |
| EP-0031080-B1 | 2-ACYLAMINOMETHYL-1,4-BENZODIAZEPINES AND THEIR SALTS, AS WELL AS A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | Kali-Chemie Pharma GmbH (DE) | 1983-09-21 | — | — | EP | disclosed |
| US-4401597-A | INTERMEDIATES FOR ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVE AND ANXIOLYTICS | HOFFMANN-LA ROCHE INC. (US) | 1983-08-30 | — | — | US | disclosed |
| US-4390471-A | INTERMEDIATES FOR IMIDOBENZODIAZEPINE AND ANALOGS | HOFFMANN-LA ROCHE INC. (US) | 1983-06-28 | — | — | US | disclosed |
| US-4382030-A | ANALGESICS; DIURETICS; ANTIARRHYTHMIC AND BRONCHODILATOR AGENTS; SEDATIVES; PSYCHOLOGICAL DISORDERS | KALI-CHEMIE PHARMA GMBH (DE) | 1983-05-03 | — | — | US | disclosed |
| US-4377523-A | Imidazodiazepines and processes therefor | HOFFMANN-LA ROCHE INC. (US) | 1983-03-22 | — | — | US | disclosed |
| US-4376075-A | REACTION OF AN AMINODERIVATIVE THEREOF WITH AN ALDEHYDE | HOFFMANN-LA ROCHE INC. (US) | 1983-03-08 | — | — | US | disclosed |
| US-4376074-A | ANTICONVULSANTS, MUSCLE RELAXANTS AND SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-03-08 | — | — | US | disclosed |
| US-4368157-A | ANTICONVULSANTS, MUSCLE RELAXANTS, TRANQUILIZERS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-01-11 | — | — | US | disclosed |
| US-4349476-A | IMIDAZO/1,5-A//1,4) BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINE | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4349477-A | IMIPAZO/1,5-A//1,4/BENZO-, THIENO- OR PYRAZOLODIAZEPINES FROM 2-DIMORPHOLINOPHOSPHONATES OF BENZO-, THIENO- OR PYRAZOLODIAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4349475-A | IMIDAZO/1,5-A//1,4/BENZO-, THIENO-, OR PYRAZOLODIAZEPINES FROM DERIVATIVES OF BENZOTHIENO-OR PYRAZOLODIAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1982-09-14 | — | — | US | disclosed |
| US-4347365-A | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1982-08-31 | — | — | US | disclosed |
| US-4347364-A | INTERMEDIATES THEREFOR | HOFFMANN-LA ROCHE INC. (US) | 1982-08-31 | — | — | US | disclosed |
| EP-0054839-A2 | 2-Acylaminomethyl-1,4-benzodiazepines and their salts, methods of preparing them and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1982-06-30 | — | — | EP | disclosed |
| US-4325957-A | ANTICONVULSANTS, ANALGESICS, ANTIARRYTHMIA, AGENTS, DIURETICS | KALI-CHEMIE PHARMA GMBH. (DE) | 1982-04-20 | — | — | US | disclosed |
| US-4280957-A | Imidazodiazepines and processes therefor | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
| EP-0031080-A1 | 2-Acylaminomethyl-1,4-benzodiazepines and their salts, as well as a process for their preparation and pharmaceutical compositions containing these compounds | Kali-Chemie Pharma GmbH (DE) | 1981-07-01 | — | — | EP | disclosed |