Purine

Purine

SCHEMBL731403

Cc1ncnc2[nH]cnc12.c1ncc2nc[nH]c2n1

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL129804 0.84 PDPK1 (0.37)
Purine SCHEMBL3021752 0.82 KDM4A (0.36)
Purine SCHEMBL6421376 0.82 KDM4A (0.38)
Purine SCHEMBL2120547 0.82 KDM4A (0.38)
Purine SCHEMBL3157 0.82
Purine SCHEMBL29456595 0.82
Adenine SCHEMBL844753 0.82 PI4KA (0.37)
Mercaptopurine Anhydrous SCHEMBL7199288 0.81
Purine SCHEMBL6959949 0.81 CHEK1 (0.33)
Purine SCHEMBL6438162 0.80 KDM4A (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 211 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478325-B1 ELIMINATION OF PROLIFERATING CELLS FROM STEM CELL-DERIVED GRAFTS RES FOUND DEV (US) 2024-07-17 EP disclosed
CN-118355023-A Method for producing therapeutic immune cells with enhanced metabolic adaptation and compositions thereof 得克萨斯大学体系董事会 2024-07-16 CN disclosed
EP-4392061-A1 CD3 EPSILON CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE THEREOF The Regents of the University of Colorado, a body corporate (US) 2024-07-03 EP disclosed
CN-118265535-A Engineered NK cells with optimally signaling CAR constructs 得克萨斯大学体系董事会 2024-06-28 CN disclosed
WO-2024137789-A2 CD3 AND ITCR EXPRESSING ENGINEERED NATURAL KILLER CELLS WITH ENHANCED FUNCTION FOR ADOPTIVE IMMUNOTHERAPY BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-06-27 WO disclosed
CN-118251227-A Antibody-loaded immune cells and methods for cancer treatment 得克萨斯大学体系董事会 2024-06-25 CN disclosed
CN-118234744-A Chimeric antigen receptor targeting HLA-G positive cancers 得克萨斯大学体系董事会 2024-06-21 CN disclosed
US-20240189357-A1 CHIMERIC ANTIGEN RECEPTORS TO TARGET CD5-POSITIVE CANCERS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2024-06-13 US disclosed
EP-4380967-A1 LAT ACTIVATING CHIMERIC ANTIGEN RECEPTOR T CELLS AND METHODS OF USE THEREOF The Regents of the University of Colorado, a body corporate (US) 2024-06-12 EP disclosed
CN-118119643-A BCMA targeting compositions and methods of use thereof 武田药品工业株式会社 2024-05-31 CN disclosed
WO-2003012049-A2 METHODS AND COMPOSITION CONCERNING HERPES VIRUS US3 AND BAD-INVOLVED APOPTOSIS UNIVERSITY OF CHICAGO (US) 2003-02-13 WO disclosed
WO-2003007889-A2 THERAPEUTIC AGENTS COMPRISING PRO-APOPTOTIC PROTEINS RESEARCH DEVELOPMENT FOUNDATION (US) 2003-01-30 WO disclosed
US-20020143062-A1 Method to incorporate N-(4-hydroxyphenyl) retinamide in liposomes BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2002-10-03 US disclosed
WO-2001025255-A9 NOVEL ZINC FINGER PROTEIN BAYLOR COLLEGE MEDICINE (US) 2002-09-26 WO disclosed
WO-2002069886-A2 MODIFIED PROTEINS, DESIGNER TOXINS, AND METHODS OF MAKING THEREOF RESEARCH DEVELOPMENT FOUNDATION (US) 2002-09-12 WO disclosed
WO-2002041871-A2 COMPOSITION COMPRISING AN IMEXON OR DERIVATIVES THEREOF AND LIPIDS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2002-05-30 WO disclosed
WO-2002032413-A2 A METHOD TO INCORPORATE N-(4-HYDROXYPHENYL) RETINAMIDE IN LIPOSOMES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2002-04-25 WO disclosed
EP-1180016-A2 METHODS AND COMPOSITIONS FOR NON-VIRAL GENE THERAPY FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES Introgen Therapeutics, Inc. (US) 2002-02-20 EP disclosed
WO-2001025255-A2 NOVEL ZINC FINGER PROTEIN BAYLOR COLLEGE OF MEDICINE (US) 2001-04-12 WO disclosed
WO-2000071096-A2 METHODS AND COMPOSITIONS FOR NON-VIRAL GENE THERAPY FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES INTROGEN THERAPEUTICS, INC. (US) 2000-11-30 WO disclosed