Adenine

Adenine

SCHEMBL844753

Nc1ncnc2[nH]cnc12.c1ncc2nc[nH]c2n1

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PI4KA P42356 4/20 0.37
PI4K2B Q8TCG2 4/20 0.37
PI4K2A Q9BTU6 4/20 0.37
PI4KB Q9UBF8 4/20 0.37
XDH P47989 2/20 0.37
LRRK2 Q5S007 2/20 0.37
LMNA P02545 1/20 0.37
DRD3 P35462 1/20 0.37
RET P07949 1/20 0.33
PRKCI P41743 1/20 0.33
KDM4E B2RXH2 2/20 0.32
MAPT P10636 2/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
RAD52 P43351 1/20 0.32
MAP4K4 O95819 2/20 0.31
ALDH1A1 P00352 1/20 0.31
APEX1 P27695 1/20 0.31
RECQL P46063 1/20 0.31
BLM P54132 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL3820887 0.84 KDM4E (0.44) LMNAKDM4EMAPTMAP4K4ALDH1A1
Adenine SCHEMBL3413247 0.84 PI4KA (0.48) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL8110 0.84 PI4KA (0.48) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL3416954 0.84 PI4KA (0.48) PI4KAPI4K2BPI4K2API4KBXDH
Adenine SCHEMBL3414603 0.84 PI4KA (0.48) PI4KAPI4K2BPI4K2API4KBXDH
Purine SCHEMBL29456595 0.84
Purine SCHEMBL3157 0.84
Purine SCHEMBL6421376 0.84 KDM4A (0.38) PI4KAPI4K2BPI4K2API4KBXDH
Purine SCHEMBL2120547 0.84 KDM4A (0.38) PI4KAPI4K2BPI4K2API4KBXDH
Purine SCHEMBL731403 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 556 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115666593-A Therapeutic agent for epithelial cancer 国立大学法人大阪大学 2023-01-31 CN claimed
US-6531581-B1 When incorporated into hairpin oligonucleotides these quench the fluorescence of fluorophores linked to the 5'-terminus of the oligonucleotide SEROLOGICALS, INC. 2003-03-11 US claimed
US-6036969-A Process for measuring cosmetic tanning and test kit therefor COTY B. V. (NL) 2000-03-14 US claimed
US-20240226275-A1 COMPOSITIONS AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION RNAimmune, Inc. (US) 2024-07-11 US disclosed
CN-118302181-A Multigang TP53 and PAN-RAS mRNA cancer vaccine 达冕生物有限公司 2024-07-05 CN disclosed
EP-4388017-A1 COMPOSITIONS AND METHODS FOR ANTI-VIRUS CHIMERIC ANTIGEN RECEPTOR Rudd, Christopher E. (CA) 2024-06-26 EP disclosed
US-20240200097-A1 AAV CAPSIDS WITH INCREASED TROPISM TO BRAIN TISSUE VOYAGER THERAPEUTICS, INC. 2024-06-20 US disclosed
EP-4384214-A2 COMPOSITION AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION Rnaimmune, Inc. (US) 2024-06-19 EP disclosed
US-11999995-B2 Methylome profiling in animals and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-04 US disclosed
CN-118119930-A Compositions and methods for mRNA vaccines against novel coronavirus infection 达冕生物有限公司 2024-05-31 CN disclosed
US-20240156947-A1 COMPOSITION AND METHODS FOR MRNA VACCINES AGAINST NOVEL OMICRON CORONAVIRUS INFECTIONS RNAimmune, Inc. (US) 2024-05-16 US disclosed
US-4912092-A Prevent tissue damage; administering purine nucleoside THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1990-03-27 US disclosed
WO-1989000854-A1 METHODS FOR INCREASING EXTRACELLULAR ADENOSINE AND FOR STABILIZING MAST CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1989-02-09 WO disclosed
EP-0301900-A2 L'utilisation de riboside ou ribotide de l'AICA pour la fabrication d'un médicament contre la crise cardiaque ou l'infarctus du myocarde aux patients souffrant d'athérosclerosis. THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1989-02-01 EP disclosed
WO-1988008450-A1 GENE THERAPY FOR METABOLITE DISORDERS FINLAYSON BIRDWELL (US) 1988-11-03 WO disclosed
EP-0270885-A1 Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids Bristol-Myers Squibb Company (US) 1988-06-15 EP disclosed
US-4713328-A DIAGNOSIS OF INFECTION USING BETA-LACTAMASE RAPIDEX LIMITED, 8402 THORNDEN TERRACE, BETHESDA, MD. 20034 A CORP. OF 1987-12-15 US disclosed
EP-0135587-A4 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS. MOLECULAR BIOSYSTEMS INC (US) 1986-04-02 EP disclosed
EP-0135587-A1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS. MOLECULAR BIOSYSTEMS INC (US) 1985-04-03 EP disclosed
WO-1984003285-A1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS MOLECULAR BIOSYSTEMS INC (US) 1984-08-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240156947-A1 COMPOSITION AND METHODS FOR MRNA VACCINES AGAINST NOVEL OMICRON CORONAVIRUS INFECTIONS RBM22, RNGTT, RBM25 PI4KA 4029/4885PI4K2B 3505/4885PI4K2A 3296/4885
US-20240226275-A1 COMPOSITIONS AND METHODS OF MRNA VACCINES AGAINST NOVEL CORONAVIRUS INFECTION RNGTT, SARS1, ACE2 PI4KA 1948/4885PI4K2B 1712/4885PI4K2A 1707/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.