Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | MMP12 | P39900 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1559008 | 0.88 | MAPT (0.79) | MAPTNPC1RAB9AMMP12ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5771609 | 0.87 | MAPT (0.77) | MAPTNPC1RAB9AMMP12ALDH1A1 | |
| SCHEMBL5068409 | 0.85 | MAPT (1.00) | MAPTNPC1RAB9AMMP12ALDH1A1 | |
| Hydrochloric Acid SCHEMBL21799330 | 0.84 | MAPT (0.97) | MAPTNPC1RAB9AMMP12ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8524166 | 0.83 | MAPT (0.70) | MAPTNPC1RAB9AMMP12ALDH1A1 | |
| SCHEMBL8525270 | 0.81 | SMN1; SMN2 (0.70) | MAPTNPC1RAB9AMMP12ALDH1A1 | |
| SCHEMBL6651931 | 0.80 | MAPT (0.65) | MAPTNPC1RAB9AMMP12ALDH1A1 | |
| SCHEMBL9095198 | 0.80 | MAPT (0.66) | MAPTNPC1RAB9AMMP12ALDH1A1 | |
| SCHEMBL16783118 | 0.80 | PKM (0.66) | MAPTNPC1RAB9AMMP12ALDH1A1 | |
| SCHEMBL10662995 | 0.78 | MAPT (0.69) | MAPTNPC1RAB9AMMP12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4721721-A | 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses | RORER PHARMACEUTICAL CORPORATION (US) | 1988-01-26 | — | — | US | claimed |
| US-4818755-A | Bicyclic heteroaryl thiazole compounds, cardiotonic compositions including the same, and their uses | RORER PHARMACEUTICAL CORPORATON (US) | 1989-04-04 | — | — | US | disclosed |
| US-4721721-A | 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses | RORER PHARMACEUTICAL CORPORATION (US) | 1988-01-26 | — | — | US | disclosed |