Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 4/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316526 | 0.92 | PDE4A (0.46) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7318905 | 0.91 | PDE4A (0.44) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7310210 | 0.90 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DCNR1 | |
| SCHEMBL7315023 | 0.90 | PDE4A (0.42) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7316041 | 0.87 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7306174 | 0.86 | PDE4A (0.49) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7316981 | 0.85 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DCNR1 | |
| SCHEMBL7314035 | 0.84 | LMNA (0.35) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7321093 | 0.82 | PDE3B (0.40) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7311023 | 0.81 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4739056-A | ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-04-19 | — | — | US | disclosed |