Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16960312 | 0.83 | TP53 (0.42) | ALDH1A1TDP1TP53TRPA1SLC6A2 | |
| SCHEMBL16951340 | 0.81 | ALDH1A1 (0.39) | ALDH1A1TDP1TP53TRPA1SLC6A2 | |
| SCHEMBL16950525 | 0.81 | ALDH1A1 (0.39) | ALDH1A1TDP1TP53TRPA1SLC6A2 | |
| SCHEMBL16955677 | 0.81 | ALDH1A1 (0.39) | ALDH1A1TDP1TP53TRPA1SLC6A2 | |
| SCHEMBL2097373 | 0.78 | LCK (0.32) | ALDH1A1 | |
| SCHEMBL2097370 | 0.78 | LCK (0.32) | ALDH1A1 | |
| SCHEMBL16958135 | 0.78 | TRPA1 (0.58) | ALDH1A1TDP1TRPA1MAPTTSHR | |
| SCHEMBL3406735 | 0.77 | ALDH1A1 (0.52) | ALDH1A1TDP1TSHR | |
| SCHEMBL7314280 | 0.77 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL19066594 | 0.77 | SLC6A2 (0.35) | ALDH1A1TDP1TP53TRPA1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845100-A | WITH HYPOTENSIVE AND ANTIINFLAMMATORY ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-04 | — | — | US | disclosed |
| EP-0202760-A2 | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-26 | — | — | EP | disclosed |