SCHEMBL7314347

SCHEMBL7314347

Cc1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)O)cc1

nearest known ligand 0.67

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 9/20 0.67
ITGA5 P08648 3/20 0.67
ITGA4 P13612 8/20 0.65
ALDH1A1 P00352 1/20 0.64
MMP2 P08253 1/20 0.61
MMP9 P14780 1/20 0.61
FKBP1A P62942 1/20 0.59
ITGA2 P17301 1/20 0.58
ITGAV P06756 1/20 0.56
ITGB7 P26010 2/20 0.54
L3MBTL1 Q9Y468 2/20 0.54
GAA P10253 1/20 0.53
HPGD P15428 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6710892 0.95 ALDH1A1 (0.70) ITGB1ITGA5ITGA4ALDH1A1MMP2
SCHEMBL6439213 0.95 ALDH1A1 (0.70) ITGB1ITGA5ITGA4ALDH1A1MMP2
SCHEMBL27514023 0.95 ALDH1A1 (0.70) ITGB1ITGA5ITGA4ALDH1A1MMP2
SCHEMBL7066469 0.95 ALDH1A1 (0.70) ITGB1ITGA5ITGA4ALDH1A1MMP2
SCHEMBL7069740 0.95 ALDH1A1 (0.70) ITGB1ITGA5ITGA4ALDH1A1MMP2
SCHEMBL7069752 0.92 ALDH1A1 (0.69) ITGB1ITGA5ITGA4ALDH1A1FKBP1A
SCHEMBL7311830 0.91 ITGB1 (0.60) ITGB1ITGA5ITGA4ALDH1A1MMP2
SCHEMBL19235515 0.91 ITGB1 (0.60) ITGB1ITGA5ITGA4ALDH1A1MMP2
SCHEMBL6714530 0.91 ITGA4 (0.66) ITGB1ITGA5ITGA4ALDH1A1FKBP1A
Methoxyamine SCHEMBL7553842 0.91 ITGB1 (0.65) ITGB1ITGA5ITGA4ALDH1A1MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6492421-B1 BINDING VERY LATE ANTIGEN-4; INFLAMMATORY DISEASES SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS, DEMENTIA, DIABETES, INFLAMMATORY BOWEL DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS, MYOCARDIAL ISCHEMIA ATHENA NEUROSCIENCES, INC. 2002-12-10 US claimed
EP-1001972-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP claimed
WO-1999006431-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO claimed
US-6492421-B1 BINDING VERY LATE ANTIGEN-4; INFLAMMATORY DISEASES SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS, DEMENTIA, DIABETES, INFLAMMATORY BOWEL DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS, MYOCARDIAL ISCHEMIA ATHENA NEUROSCIENCES, INC. 2002-12-10 US disclosed
CN-1265668-A Substituted phenylalanine-type compounds that inhibit VLA-4 mediated leukocyte adhesion ELAND PHARMACEUTICALS CO (US) 2000-09-06 CN disclosed
EP-1001972-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP disclosed
WO-1999006431-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO disclosed