Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.55 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.50 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.50 |
| ▸ | CTSC | P53634 | 2/20 | 0.48 |
| ▸ | CTSL | P07711 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 5/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.45 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314446 | 1.00 | GPR139 (0.55) | GPR139SLC6A9SLC6A5CTSCCTSL | |
| SCHEMBL40779 | 0.85 | CTRB1 (0.58) | CTSLCTSSCTSKCTRB1 | |
| SCHEMBL40780 | 0.85 | CTRB1 (0.58) | CTSLCTSSCTSKCTRB1 | |
| SCHEMBL11863650 | 0.83 | CTSC (0.62) | SLC6A9SLC6A5CTSCCTSLCTSS | |
| SCHEMBL11863638 | 0.83 | CTSC (0.62) | SLC6A9SLC6A5CTSCCTSLCTSS | |
| SCHEMBL3792436 | 0.81 | CTSC (0.46) | CTSCCTSLCTSSCTSKCTRB1 | |
| SCHEMBL2574911 | 0.80 | CTRB1 (0.50) | CTSCCTRB1 | |
| SCHEMBL2574907 | 0.80 | CTRB1 (0.50) | CTSCCTRB1 | |
| SCHEMBL11403190 | 0.80 | CTSC (0.50) | CTSC | |
| SCHEMBL828728 | 0.80 | ACE (0.65) | GPR139SLC6A9SLC6A5CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |