Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 14/20 | 0.57 |
| ▸ | CA9 | Q16790 | 11/20 | 0.57 |
| ▸ | ELANE | P08246 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309421 | 0.83 | CA12 (0.54) | CA12CA9ELANECA2RAB9A | |
| SCHEMBL7305467 | 0.78 | ELANE (0.64) | CA12CA9ELANECA2RAB9A | |
| SCHEMBL6958970 | 0.74 | CA12 (0.71) | CA12CA9ELANECA2 | |
| SCHEMBL30527996 | 0.73 | CA12 (1.00) | CA12CA9ELANECA2 | |
| SCHEMBL1172438 | 0.73 | CA12 (1.00) | CA12CA9ELANECA2 | |
| SCHEMBL5899155 | 0.73 | ELANE (1.00) | CA12CA9ELANECA2 | |
| SCHEMBL7290946 | 0.73 | CA12 (0.69) | CA12CA9ELANECA2 | |
| SCHEMBL1101896 | 0.73 | CA12 (1.00) | CA12CA9ELANECA2 | |
| SCHEMBL7281348 | 0.73 | CA12 (0.69) | CA12CA9ELANECA2 | |
| SCHEMBL356403 | 0.73 | CA12 (0.69) | CA12CA9ELANECA2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874432-A | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1999-02-23 | — | — | US | disclosed |
| EP-0471756-B1 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF | SANOFI SA (FR) | 1997-10-29 | — | — | EP | disclosed |
| US-5650422-A | TREATMENT OF EMPHYSEMA, ARTHRITIS OR PANCREATITIS | SANOFI (FR) | 1997-07-22 | — | — | US | disclosed |
| US-5596012-A | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5371074-A | Use of saccharin derivatives as proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-12-06 | — | — | US | disclosed |
| US-5236917-A | Respiratory system disorders, antiarthritic agents | STERLING WINTHROP INC. (US) | 1993-08-17 | — | — | US | disclosed |
| EP-0542372-A1 | 2-Substituted saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |
| EP-0471756-A4 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF | — | 1992-04-08 | — | — | EP | disclosed |
| EP-0471756-A1 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF. | STERLING WINTHROP INC (US) | 1992-02-26 | — | — | EP | disclosed |
| WO-1990013549-A1 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF | STERLING WINTHROP INC. (US) | 1990-11-15 | — | — | WO | disclosed |