Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.77 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.75 |
| ▸ | RECQL | P46063 | 1/20 | 0.75 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.69 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.69 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.69 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.69 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.69 |
| ▸ | BRD4 | O60885 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | CNR1 | P21554 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | GABRP | O00591 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11823357 | 0.90 | OPRK1 (0.73) | HPGDOPRK1SMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11601414 | 0.89 | HPGD (0.74) | HPGDOPRK1SMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11384511 | 0.88 | GABRA1 (0.70) | HPGDOPRK1SMN1; SMN2RECQLGABRA1 | |
| SCHEMBL7321230 | 0.88 | OPRK1 (0.80) | HPGDOPRK1SMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11361255 | 0.87 | GABRA1 (0.69) | HPGDOPRK1SMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11733783 | 0.87 | HPGD (0.70) | HPGDOPRK1SMN1; SMN2RECQLGABRA1 | |
| SCHEMBL7323595 | 0.87 | OPRK1 (0.75) | HPGDOPRK1SMN1; SMN2RECQLGABRA1 | |
| SCHEMBL10738545 | 0.87 | OPRK1 (0.78) | HPGDOPRK1SMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11754993 | 0.87 | HPGD (0.70) | HPGDOPRK1SMN1; SMN2RECQLGABRA1 | |
| SCHEMBL11601149 | 0.87 | OPRK1 (0.71) | HPGDOPRK1SMN1; SMN2RECQLGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219541-B1 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1989-09-20 | — | — | EP | claimed |
| EP-0219541-A1 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES. | UPJOHN CO (US) | 1987-04-29 | — | — | EP | claimed |
| WO-1986006631-A2 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1986-11-20 | — | — | WO | claimed |
| US-4264615-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-04-28 | — | — | US | claimed |
| EP-0219541-B1 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1989-09-20 | — | — | EP | disclosed |
| EP-0219541-A1 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES. | UPJOHN CO (US) | 1987-04-29 | — | — | EP | disclosed |
| WO-1986006631-A2 | TREATMENT OF PREMENSTRUAL SYNDROMES USING TRIAZOLOBENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1986-11-20 | — | — | WO | disclosed |
| US-4264615-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-04-28 | — | — | US | disclosed |
| US-4250094-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS, AND ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-02-10 | — | — | US | disclosed |
| US-4235775-A | Triazolobenzodiazepine derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-11-25 | — | — | US | disclosed |