SCHEMBL7314860

SCHEMBL7314860

CCOC(=O)CCNC(=O)C(Cc1ccc(-c2ccccc2)cc1)NCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.41
MMEL1 Q495T6 1/20 0.40
FPR2 P25090 1/20 0.40
EED O75530 1/20 0.39
CTSS P25774 1/20 0.38
CTSK P43235 1/20 0.38
ADCY6 O43306 1/20 0.38
ADCY3 O60266 1/20 0.38
ADCY9 O60503 1/20 0.38
ADCY5 O95622 1/20 0.38
ADCY8 P40145 1/20 0.38
GCGR P47871 1/20 0.38
ADCY7 P51828 1/20 0.38
ADCY2 Q08462 1/20 0.38
ADCY1 Q08828 1/20 0.38
ADCY4 Q8NFM4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7314533 0.91 MMEL1 (0.50) L3MBTL1MMEL1ADCY6ADCY3ADCY9
SCHEMBL7319527 0.90 L3MBTL1 (0.42) L3MBTL1MMEL1FPR2EED
SCHEMBL7354164 0.85 L3MBTL1 (0.46) L3MBTL1MMEL1EEDCTSS
SCHEMBL7348239 0.84 L3MBTL1 (0.44) L3MBTL1MMEL1CTSS
SCHEMBL7348558 0.83 MME (0.48) L3MBTL1MMEL1
SCHEMBL7312321 0.83 MME (0.48) L3MBTL1MMEL1
SCHEMBL7343787 0.83 MMEL1 (0.51) L3MBTL1MMEL1ADCY6ADCY3ADCY9
SCHEMBL7318799 0.79 L3MBTL1 (0.41) L3MBTL1MMEL1EED
SCHEMBL7311112 0.79 L3MBTL1 (0.40) L3MBTL1MMEL1EED
SCHEMBL7312849 0.78 L3MBTL1 (0.37) L3MBTL1MMEL1FPR2EED

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0511940-A2 Phosphono/biaryl substituted dipeptide derivatives CIBA-GEIGY AG (CH) 1992-11-04 EP claimed
EP-0592367-A2 Phosphono/biaryl substituted dipeptide derivatives CIBA-GEIGY AG (CH) 1994-04-13 EP disclosed
EP-0511940-A2 Phosphono/biaryl substituted dipeptide derivatives CIBA-GEIGY AG (CH) 1992-11-04 EP disclosed
US-5155100-A Treating cardiovascular disorders in mammals CIBA-GEIGY CORPORATION (US) 1992-10-13 US disclosed