Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 5/20 | 0.59 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313782 | 0.93 | YAP1 (0.63) | YAP1GPR119ITGB3ITGA2BSTS | |
| SCHEMBL7313355 | 0.88 | KDM4E (0.55) | YAP1GPR119 | |
| SCHEMBL7314939 | 0.87 | YAP1 (0.57) | YAP1GPR119ITGB3ITGA2BSTS | |
| SCHEMBL7320864 | 0.86 | GPR119 (0.60) | YAP1GPR119 | |
| SCHEMBL7312363 | 0.84 | GPR119 (0.62) | YAP1GPR119ITGB3ITGA2B | |
| SCHEMBL7309801 | 0.84 | YAP1 (0.63) | YAP1GPR119ITGB3ITGA2BITGAV | |
| SCHEMBL7315022 | 0.84 | GPR119 (0.64) | YAP1GPR119 | |
| SCHEMBL7308698 | 0.83 | GPR119 (0.63) | YAP1GPR119ITGB3ITGA2B | |
| SCHEMBL7282956 | 0.82 | YAP1 (0.64) | YAP1GPR119ITGB3ITGA2BSTS | |
| SCHEMBL7280692 | 0.82 | GPR119 (0.62) | YAP1GPR119ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993016697-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1993-09-02 | — | — | WO | claimed |
| WO-1993016697-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1993-09-02 | — | — | WO | disclosed |
| US-5227490-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1993-07-13 | — | — | US | disclosed |