SCHEMBL7315308

SCHEMBL7315308

Cc1nn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c(-c2ccccc2)nc1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.43
NPC1 O15118 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
RAB9A P51151 1/20 0.43
NR1H3 Q13133 3/20 0.41
LMNA P02545 2/20 0.41
GAA P10253 2/20 0.41
ALDH1A1 P00352 2/20 0.41
CASP3 P42574 1/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
NR1H2 P55055 2/20 0.40
AGTR1 P30556 3/20 0.38
AGTR2 P50052 3/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.37
TBXA2R P21731 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7318186 0.91 ALDH1A1 (0.40) SMN1; SMN2NPC1CYP1A2CYP3A4CYP2C9
SCHEMBL7319415 0.87 NR1H3 (0.40) SMN1; SMN2NPC1CYP1A2CYP3A4CYP2C9
SCHEMBL7323987 0.84 AGTR1 (0.53) AGTR1AGTR2
SCHEMBL6005914 0.82 AGTR1 (0.55) AGTR1AGTR2
SCHEMBL7322677 0.80 MAPT (0.39) SMN1; SMN2RAB9ALMNAALDH1A1AGTR1
SCHEMBL6004470 0.80 PTGDR2 (0.39) AGTR1AGTR2PTGDR2
SCHEMBL6005747 0.80 NR1H4 (0.40) SMN1; SMN2NPC1CYP1A2CYP3A4CYP2C9
SCHEMBL6007319 0.80 AGTR1 (0.41) AGTR1AGTR2
SCHEMBL6006795 0.80 PTGDR2 (0.39) SMN1; SMN2NPC1CYP1A2CYP3A4CYP2C9
SCHEMBL6006037 0.79 IDO1 (0.40) SMN1; SMN2NPC1CYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6071913-A 2-(1H-TETRAZOL-5-YL)-4'-(AS-TRIAZIN-YLMETHYL)BIPHENYLS; CARDIOVASCULAR DISEASES, ESPECIALLY HYPERTENSION AND CONGESTIVE HEART FAILURE DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) 2000-06-06 US disclosed