Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313785 | 0.77 | GAA (0.47) | GAAMAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL3715950 | 0.77 | KMT2A (0.41) | GAAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL31194569 | 0.77 | GAA (0.55) | GAAMAPTMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL8914855 | 0.75 | HPGD (0.33) | GAASMN1; SMN2TSHRHPGD | |
| SCHEMBL31194577 | 0.75 | GAA (0.54) | GAAMAPTMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL4171729 | 0.74 | GAA (0.55) | GAASMN1; SMN2HPGD | |
| SCHEMBL3716061 | 0.73 | TSHR (0.43) | GAAMAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL31194662 | 0.72 | GAA (0.51) | GAAMAPTMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL3721267 | 0.72 | KMT2A (0.36) | MAPTSMN1; SMN2MEN1KMT2ARECQL | |
| SCHEMBL7316030 | 0.71 | ALDH1A1 (0.45) | GAAMAPTMAPK1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |