Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.30 |
| ▸ | TUBB | P07437 | 1/20 | 0.30 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.30 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.30 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.30 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.30 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.30 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10680998 | 0.82 | TUBB4A (0.33) | NR3C1NR3C2HTTTUBB4ATUBB | |
| SCHEMBL7316258 | 0.81 | HPGD (0.35) | HPGDHSD17B10NR3C1NR3C2 | |
| SCHEMBL7317980 | 0.81 | HPGD (0.35) | HPGDHSD17B10MBOAT4HTTNOTUM | |
| SCHEMBL10574492 | 0.80 | HPGD (0.35) | HPGDHSD17B10 | |
| SCHEMBL10574489 | 0.80 | HPGD (0.35) | HPGDHSD17B10 | |
| SCHEMBL7309063 | 0.78 | HPGD (0.39) | HPGDHSD17B10HSP90AA1HSP90AB1HSD11B1 | |
| SCHEMBL7321591 | 0.76 | HPGD (0.32) | HPGDHSD17B10 | |
| SCHEMBL30242169 | 0.74 | NR2E1 (0.57) | HPGDHSD17B10HSP90AA1HSP90AB1NR2E1 | |
| SCHEMBL4713291 | 0.73 | NR2E1 (0.42) | NR2E1NR3C1NR3C2 | |
| SCHEMBL13122900 | 0.70 | NOTUM (0.37) | HPGDHSD17B10HSP90AA1HSP90AB1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900839-A | SUBSTITUTED PHENYLPROPENAMIDES | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4837334-A | Precursors to quinolone inotropic agents | PFIZER INC. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4728653-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0166533-A1 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-01-02 | — | — | EP | disclosed |