Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317493 | 0.85 | SLC2A1 (0.52) | MEN1KMT2ASLC2A1HTTSMN1; SMN2 | |
| SCHEMBL9825369 | 0.85 | KCNH2 (0.50) | MEN1KMT2ASLC2A1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7320769 | 0.84 | KCNH2 (0.49) | MEN1KMT2ASLC2A1HTTSMN1; SMN2 | |
| SCHEMBL9825118 | 0.83 | SLC2A1 (0.43) | MEN1KMT2ASLC2A1HTTSMN1; SMN2 | |
| SCHEMBL9824522 | 0.79 | SLC2A1 (0.48) | MEN1KMT2ASLC2A1HTTSMN1; SMN2 | |
| SCHEMBL9824218 | 0.79 | SLC2A1 (0.48) | MEN1KMT2ASLC2A1HTTSMN1; SMN2 | |
| SCHEMBL7312568 | 0.79 | SIGMAR1 (0.47) | MEN1KMT2ASLC2A1HTTSMN1; SMN2 | |
| Fumaric Acid SCHEMBL7311253 | 0.78 | ALDH1A1 (0.42) | MEN1KMT2ASLC2A1HTTSMN1; SMN2 | |
| Fumaric Acid SCHEMBL10690449 | 0.75 | SLC2A1 (0.40) | MEN1KMT2ASLC2A1SIGMAR1HTR2A | |
| SCHEMBL14438281 | 0.70 | SIGMAR1 (0.54) | MEN1KMT2ASIGMAR1KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4742084-A | Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives | MCNEILAB, INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4661635-A | ANTIARRHYTHMIA AGENTS | MCNEILAB, INC. (US) | 1987-04-28 | — | — | US | disclosed |
| EP-0146271-A2 | Aralykyl (arylethynyl) aralkyl amines for use as vasodilators and antihypertensives | McNeilab, Inc. (US) | 1985-06-26 | — | — | EP | disclosed |