Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.51 |
| ▸ | PDE6C | P51160 | 1/20 | 0.48 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6194610 | 0.80 | KMT2A (0.53) | PDE5A | |
| SCHEMBL7310252 | 0.73 | PDE5A (0.50) | PDE5APDE6CPDE11A | |
| SCHEMBL6197392 | 0.73 | PDE5A (0.83) | PDE5APDE6CPDE11A | |
| SCHEMBL16188276 | 0.72 | TSHR (0.56) | PDE5APDE6CPDE11A | |
| SCHEMBL6774601 | 0.72 | PDE5A (0.70) | PDE5APDE6CPDE11A | |
| SCHEMBL6199648 | 0.69 | PDE5A (0.75) | PDE5APDE6CPDE11A | |
| SCHEMBL7312580 | 0.69 | LMNA (0.42) | PDE5A | |
| SCHEMBL7307870 | 0.68 | PDE5A (0.59) | PDE5APDE6CPDE11A | |
| SCHEMBL5827896 | 0.67 | PDE5A (0.63) | PDE5APDE6CPDE11A | |
| SCHEMBL2566273 | 0.67 | PDE5A (1.00) | PDE5APDE6CPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407114-B1 | BENIGN PROSTATIC HYPERPLASIA, CARDIOVASCULAR, GASTROINTESTINAL AND RESPIRATORY DISORDER TREATMENT; ANTIASTHMATIC, ANTIALLERGEN, AND ANTIDIABETIC AGENTS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-0995751-A2 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. (US) | 2000-04-26 | — | — | EP | disclosed |