Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.63 |
| ▸ | MME | P08473 | 2/20 | 0.63 |
| ▸ | LTA4H | P09960 | 5/20 | 0.60 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10741404 | 0.90 | LTA4H (0.62) | ACELTA4HACE2 | |
| SCHEMBL10739592 | 0.89 | LTA4H (0.61) | ACELTA4HACE2 | |
| SCHEMBL9069201 | 0.87 | ACE (0.60) | ACELTA4HACE2 | |
| SCHEMBL9068758 | 0.87 | ACE (0.60) | ACELTA4HACE2 | |
| SCHEMBL10766372 | 0.87 | ACE (0.60) | ACELTA4HACE2 | |
| SCHEMBL9069203 | 0.87 | ACE (0.60) | ACELTA4HACE2 | |
| SCHEMBL9090988 | 0.87 | ACE (0.60) | ACELTA4HACE2 | |
| SCHEMBL9068759 | 0.87 | ACE (0.60) | ACELTA4HACE2 | |
| SCHEMBL7327852 | 0.86 | LTA4H (0.56) | ACELTA4HACE2 | |
| SCHEMBL7381708 | 0.85 | ACE (0.76) | ACELTA4HACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |
| US-5262436-A | Administering; enzyme inhibitor | SCHERING CORPORATION (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0566157-A1 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5061710-A | Atrial natriuretic factors | SCHERING CORPORATION (US) | 1991-10-29 | — | — | US | disclosed |
| US-4929641-A | DIURETICS, ANGIOTENSIN CONVERTING ENZYMES | SCHERING CORPORATION (US) | 1990-05-29 | — | — | US | disclosed |
| US-4801609-A | Mercapto-acylamino acid antihypertensives | SCHERING CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |