Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.45 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316108 | 1.00 | KIF11 (0.45) | KIF11SLC6A12NPC1MAPTMAPK1 | |
| SCHEMBL7325057 | 0.91 | PDK2 (0.43) | KIF11SLC6A12KMT2APDK2 | |
| SCHEMBL7325065 | 0.91 | PDK2 (0.43) | KIF11SLC6A12KMT2APDK2 | |
| SCHEMBL7317367 | 0.90 | KIF11 (0.44) | KIF11MAPTKMT2ASLC1A3SLC1A2 | |
| SCHEMBL7317362 | 0.90 | KIF11 (0.44) | KIF11MAPTKMT2ASLC1A3SLC1A2 | |
| SCHEMBL7323867 | 0.90 | KIF11 (0.44) | KIF11MAPTKMT2ASLC1A3SLC1A2 | |
| SCHEMBL7323752 | 0.87 | KIF11 (0.37) | KIF11MAPTPDK2 | |
| SCHEMBL7323759 | 0.87 | KIF11 (0.37) | KIF11MAPTPDK2 | |
| SCHEMBL7318078 | 0.86 | CYP2C19 (0.49) | KIF11KMT2APDK2 | |
| SCHEMBL7323278 | 0.86 | KIF11 (0.49) | KIF11NPC1KMT2ASLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | claimed |
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |