Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323867 | 1.00 | KIF11 (0.44) | KIF11ATMSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7317362 | 1.00 | KIF11 (0.44) | KIF11ATMSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7323274 | 0.91 | KIF11 (0.49) | KIF11ATMSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7318074 | 0.91 | CYP2C19 (0.49) | KIF11CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL7318078 | 0.91 | CYP2C19 (0.49) | KIF11CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL7323278 | 0.91 | KIF11 (0.49) | KIF11ATMSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7312848 | 0.90 | KIF11 (0.41) | KIF11ATMSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7320455 | 0.90 | KIF11 (0.41) | KIF11ATMSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7312855 | 0.90 | KIF11 (0.41) | KIF11ATMSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7320450 | 0.90 | KIF11 (0.41) | KIF11ATMSLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | claimed |
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |