Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.52 |
| ▸ | PDE4A | P27815 | 6/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | VEGFA | P15692 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388242 | 0.86 | PDE4A (0.54) | PDE4BPDE4APDE4DPDE4CPDE3A | |
| SCHEMBL1388244 | 0.86 | PDE4A (0.54) | PDE4BPDE4APDE4DPDE4CPDE3A | |
| SCHEMBL8482836 | 0.81 | PDE4A (0.57) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL8482828 | 0.81 | PDE4A (0.57) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL8481926 | 0.81 | PDE4B (0.55) | PDE4BPDE4APDE4DPDE4CPDE3A | |
| SCHEMBL1388172 | 0.80 | ALDH1A1 (0.68) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL1388171 | 0.80 | ALDH1A1 (0.68) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL1389060 | 0.80 | ALDH1A1 (0.68) | PDE4BPDE4APDE4DPDE4CALDH1A1 | |
| SCHEMBL1389074 | 0.80 | PDE4B (0.52) | PDE4BPDE4APDE4DPDE4CPDE3A | |
| SCHEMBL1389073 | 0.80 | PDE4B (0.52) | PDE4BPDE4APDE4DPDE4CPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723460-A | Cyclo (alkyl and alkenyl) phenyl-alkenylyl heteroaryl compounds and pharmaceutical compositions containing same | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-03-03 | — | — | US | claimed |
| US-5962483-A | ANTIASTHMA AGENTS; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS, LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5962492-A | ANTIASTHMA AGENTS; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5739144-A | INHIBITORS OF PHOSPHODIESTERASE ENZYMES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |
| US-5723460-A | Cyclo (alkyl and alkenyl) phenyl-alkenylyl heteroaryl compounds and pharmaceutical compositions containing same | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-03-03 | — | — | US | disclosed |