Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.52 |
| ▸ | PDE4A | P27815 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1389073 | 1.00 | PDE4B (0.52) | PDE4BPDE4AALDH1A1MAPTHPGD | |
| SCHEMBL1388172 | 0.86 | ALDH1A1 (0.68) | PDE4BPDE4AALDH1A1MAPTHPGD | |
| SCHEMBL1389060 | 0.86 | ALDH1A1 (0.68) | PDE4BPDE4AALDH1A1MAPTHPGD | |
| SCHEMBL1388171 | 0.86 | ALDH1A1 (0.68) | PDE4BPDE4AALDH1A1MAPTHPGD | |
| SCHEMBL7316971 | 0.85 | PDE4B (0.51) | PDE4BPDE4AALDH1A1MAPTHPGD | |
| SCHEMBL7784010 | 0.85 | PDE4B (0.51) | PDE4BPDE4AALDH1A1MAPTHPGD | |
| SCHEMBL1388242 | 0.84 | PDE4A (0.54) | PDE4BPDE4AALDH1A1PDE4DPDE4C | |
| SCHEMBL1388244 | 0.84 | PDE4A (0.54) | PDE4BPDE4AALDH1A1PDE4DPDE4C | |
| SCHEMBL8481926 | 0.81 | PDE4B (0.55) | PDE4BPDE4AALDH1A1MAPTHPGD | |
| SCHEMBL7316150 | 0.80 | PDE4B (0.52) | PDE4BPDE4AALDH1A1MAPTPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | claimed |
| JP-H08501801-A | — | — | 1996-02-27 | — | — | JP | claimed |
| EP-0640070-A1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS. | CELLTECH THERAPEUTICS LTD (GB) | 1995-03-01 | — | — | EP | claimed |
| WO-1994020455-A1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-09-15 | — | — | WO | claimed |
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | disclosed |
| US-5633257-A | PHOSPHODIESTERASE INHIBITOR | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-27 | — | — | US | disclosed |
| EP-0640070-A1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS. | CELLTECH THERAPEUTICS LTD (GB) | 1995-03-01 | — | — | EP | disclosed |
| WO-1994020455-A1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |