Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 15/20 | 0.48 |
| ▸ | MMP13 | P45452 | 13/20 | 0.48 |
| ▸ | MMP1 | P03956 | 13/20 | 0.48 |
| ▸ | MMP2 | P08253 | 9/20 | 0.47 |
| ▸ | MMP3 | P08254 | 7/20 | 0.47 |
| ▸ | MMP8 | P22894 | 6/20 | 0.47 |
| ▸ | MMP12 | P39900 | 6/20 | 0.47 |
| ▸ | MMP14 | P50281 | 6/20 | 0.47 |
| ▸ | MMP16 | P51512 | 6/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323399 | 0.92 | MMP9 (0.49) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7325505 | 0.90 | MMP9 (0.46) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7319004 | 0.90 | MMP9 (0.48) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7322414 | 0.90 | TP53 (0.45) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7321840 | 0.88 | MMP9 (0.44) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7317327 | 0.87 | MMP9 (0.46) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7314335 | 0.87 | MMP9 (0.44) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7323420 | 0.86 | NPC1 (0.43) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7319446 | 0.85 | MMP9 (0.49) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7311965 | 0.84 | MMP13 (0.47) | MMP9MMP13MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |