SCHEMBL7316173

SCHEMBL7316173

CCCCCN1CCC(CCO)CC1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GNAO1 P09471 8/20 0.61
GNAI3 P08754 7/20 0.53
GNAI1 P63096 7/20 0.53
KCNH2 Q12809 2/20 0.50
HRH3 Q9Y5N1 2/20 0.44
CHRM1 P11229 2/20 0.44
CHRM2 P08172 1/20 0.44
CHRM4 P08173 1/20 0.44
HTR1A P08908 1/20 0.44
CHRM5 P08912 1/20 0.44
ADRA2A P08913 1/20 0.44
DRD2 P14416 1/20 0.44
ADRA2B P18089 1/20 0.44
CHRM3 P20309 1/20 0.44
DRD4 P21917 1/20 0.44
ADRA1D P25100 1/20 0.44
ADRA1A P35348 1/20 0.44
HRH1 P35367 1/20 0.44
ADRA1B P35368 1/20 0.44
ACHE P22303 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7319420 0.98 GNAO1 (0.64) GNAO1GNAI3GNAI1KCNH2
SCHEMBL7738066 0.98 GNAO1 (0.64) GNAO1GNAI3GNAI1KCNH2
SCHEMBL6951732 0.94 GNAO1 (0.54) GNAO1GNAI3GNAI1KCNH2HRH3
SCHEMBL7321984 0.91 GNAO1 (0.59) GNAO1GNAI3GNAI1KCNH2HRH3
SCHEMBL9344937 0.89 GNAO1 (0.50) GNAO1GNAI3GNAI1KCNH2HTR1A
SCHEMBL23767405 0.88 GNAO1 (0.74) GNAO1GNAI3GNAI1KCNH2HRH3
SCHEMBL7321853 0.86 GNAO1 (0.45) GNAO1GNAI3GNAI1HRH3CHRM1
SCHEMBL17424035 0.86 GNAO1 (0.67) GNAO1GNAI3GNAI1KCNH2HRH3
Hydrochloric Acid SCHEMBL11479318 0.86 GNAO1 (0.63) GNAO1GNAI3GNAI1KCNH2CHRM1
Hydrochloric Acid SCHEMBL11489213 0.86 GNAO1 (0.63) GNAO1GNAI3GNAI1KCNH2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0629190-A1 COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-12-21 EP disclosed
WO-1993015052-A1 COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-08-05 WO disclosed
EP-0542846-A1 N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1993-05-26 EP disclosed
CN-1061963-A Be used as the croak pyridine class of the 4-replacement of medicine SMITH KLINE FRENCH LAB (GB) 1992-06-17 CN disclosed
WO-1992002502-A1 N-HYDROCARBYL-4-SUBSTITUTED PIPERIDINES, THEIR PREPARATION AND USE AS CALCIUM BLOCKING AGENTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1992-02-20 WO disclosed