Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 3/20 | 0.50 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 6/20 | 0.43 |
| ▸ | DRD1 | P21728 | 6/20 | 0.43 |
| ▸ | DRD4 | P21917 | 6/20 | 0.43 |
| ▸ | DRD5 | P21918 | 6/20 | 0.43 |
| ▸ | DRD3 | P35462 | 6/20 | 0.43 |
| ▸ | GUSB | P08236 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316173 | 0.89 | GNAO1 (0.61) | GNAO1GNAI3GNAI1KCNH2HTR1A | |
| SCHEMBL21160746 | 0.89 | GNAO1 (0.50) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| SCHEMBL7738066 | 0.88 | GNAO1 (0.64) | GNAO1GNAI3GNAI1KCNH2GBA1 | |
| SCHEMBL7319420 | 0.88 | GNAO1 (0.64) | GNAO1GNAI3GNAI1KCNH2GBA1 | |
| SCHEMBL24711785 | 0.87 | GNAO1 (0.54) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| SCHEMBL25531092 | 0.87 | GBA1 (0.41) | GNAO1GBA1DRD1DRD4DRD5 | |
| Fluoride SCHEMBL30330671 | 0.86 | GNAO1 (0.53) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| SCHEMBL21370302 | 0.86 | GNAO1 (0.57) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| Hydrochloric Acid SCHEMBL30330945 | 0.86 | GNAO1 (0.57) | GNAO1GNAI3GNAI1BCHEKCNH2 | |
| SCHEMBL9368277 | 0.86 | GNAO1 (0.53) | GNAO1GNAI3GNAI1BCHEKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600955-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-06-15 | — | — | EP | disclosed |
| EP-0589971-A1 | COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993003725-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-03-04 | — | — | WO | disclosed |
| WO-1992022527-A2 | 3-SUBSTITUTED PYRROLIDINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1992-12-23 | — | — | WO | disclosed |