Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316200 | 0.81 | NOTUM (0.51) | LMNANOTUMTNFNOD2NOD1 | |
| SCHEMBL2209599 | 0.81 | LMNA (0.68) | LMNANOTUMTNFNOD2NOD1 | |
| SCHEMBL12428954 | 0.81 | LMNA (0.68) | LMNANOTUMTNFNOD2NOD1 | |
| SCHEMBL2205547 | 0.81 | LMNA (0.68) | LMNANOTUMTNFNOD2NOD1 | |
| SCHEMBL7308465 | 0.81 | LMNA (0.37) | LMNANOTUM | |
| SCHEMBL7311635 | 0.79 | NOTUM (0.60) | NOTUM | |
| SCHEMBL7321256 | 0.79 | NOTUM (0.60) | NOTUM | |
| SCHEMBL1760527 | 0.77 | LMNA (0.50) | LMNANOTUMTNFNOD2NOD1 | |
| SCHEMBL1760639 | 0.76 | NOTUM (0.52) | LMNANOTUMTNFNOD2NOD1 | |
| SCHEMBL10920057 | 0.72 | NOTUM (0.44) | LMNANOTUMTNFNOD2NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0050850-A1 | 1-Carboxyalkanoylindolin-2-carboxylic acids and derivatives thereof, processes for their preparation, and pharmaceutical compositions containing these compounds | CIBA-GEIGY AG (CH) | 1982-05-05 | — | — | EP | disclosed |