Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321256 | 1.00 | NOTUM (0.60) | NOTUMNPC1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL8522019 | 0.83 | BCHE (0.46) | NOTUMNPC1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7366208 | 0.82 | ACE (0.46) | ACE | |
| SCHEMBL7359614 | 0.80 | ACE (0.44) | ACE | |
| SCHEMBL1445012 | 0.80 | AADAT (0.41) | NOTUMNPC1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7316205 | 0.79 | LMNA (0.49) | NOTUM | |
| SCHEMBL10646920 | 0.78 | NPC1 (0.52) | NPC1CYP2C19ACE | |
| SCHEMBL7321116 | 0.78 | CYP1A2 (0.43) | NPC1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7475934 | 0.78 | NPC1 (0.52) | NPC1CYP2C19ACE | |
| SCHEMBL7322632 | 0.78 | ACE (0.51) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0050850-A1 | 1-Carboxyalkanoylindolin-2-carboxylic acids and derivatives thereof, processes for their preparation, and pharmaceutical compositions containing these compounds | CIBA-GEIGY AG (CH) | 1982-05-05 | — | — | EP | disclosed |