Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 17/20 | 0.53 |
| ▸ | MMP9 | P14780 | 16/20 | 0.53 |
| ▸ | MMP2 | P08253 | 8/20 | 0.53 |
| ▸ | MMP8 | P22894 | 8/20 | 0.53 |
| ▸ | MMP12 | P39900 | 8/20 | 0.53 |
| ▸ | MMP14 | P50281 | 8/20 | 0.53 |
| ▸ | MMP16 | P51512 | 8/20 | 0.53 |
| ▸ | MMP1 | P03956 | 14/20 | 0.50 |
| ▸ | MMP3 | P08254 | 6/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321236 | 0.91 | MMP13 (0.44) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7315547 | 0.91 | MMP13 (0.46) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7323907 | 0.87 | MMP13 (0.56) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7321902 | 0.87 | MMP13 (0.56) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7323355 | 0.86 | MMP13 (0.55) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7323945 | 0.85 | MMP13 (0.56) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7312079 | 0.84 | MMP13 (0.53) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7316368 | 0.84 | MMP13 (0.53) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7320799 | 0.84 | MMP13 (0.53) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7323471 | 0.82 | MMP13 (0.51) | MMP13MMP9MMP2MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |