Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 16/20 | 0.53 |
| ▸ | MMP9 | P14780 | 16/20 | 0.53 |
| ▸ | MMP2 | P08253 | 9/20 | 0.53 |
| ▸ | MMP8 | P22894 | 8/20 | 0.53 |
| ▸ | MMP12 | P39900 | 8/20 | 0.53 |
| ▸ | MMP14 | P50281 | 8/20 | 0.53 |
| ▸ | MMP16 | P51512 | 8/20 | 0.53 |
| ▸ | MMP1 | P03956 | 12/20 | 0.50 |
| ▸ | MMP3 | P08254 | 6/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321902 | 0.93 | MMP13 (0.56) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7323471 | 0.91 | MMP13 (0.51) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7316229 | 0.91 | MMP13 (0.51) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7323198 | 0.91 | MMP2 (0.44) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7322110 | 0.91 | MMP2 (0.46) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7322624 | 0.90 | MMP13 (0.49) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7320799 | 0.89 | MMP13 (0.53) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7311793 | 0.89 | MMP1 (0.48) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7315919 | 0.89 | MMP13 (0.48) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL7316297 | 0.88 | MMP13 (0.48) | MMP13MMP9MMP2MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |