Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.59 |
| ▸ | ACE | P12821 | 2/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 6/20 | 0.47 |
| ▸ | ELANE | P08246 | 6/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 2/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | MLX | Q9UH92 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355181 | 0.93 | MALT1 (0.59) | MALT1CMA1ELANEREN | |
| SCHEMBL7320477 | 0.92 | CMA1 (0.53) | MALT1ACEACE2CMA1ELANE | |
| SCHEMBL7285949 | 0.90 | CMA1 (0.53) | MALT1CMA1ELANECTSLPREP | |
| SCHEMBL7323606 | 0.90 | CMA1 (0.53) | MALT1CMA1ELANECTSLPREP | |
| SCHEMBL7316334 | 0.87 | MALT1 (0.57) | MALT1ACEACE2CMA1ELANE | |
| SCHEMBL7317461 | 0.87 | MALT1 (0.53) | MALT1CMA1ELANE | |
| SCHEMBL7317019 | 0.87 | MALT1 (0.53) | MALT1ACEACE2CMA1ELANE | |
| SCHEMBL7317148 | 0.87 | MALT1 (0.61) | MALT1ACEACE2CMA1ELANE | |
| SCHEMBL7313441 | 0.86 | MALT1 (0.52) | MALT1CMA1ELANE | |
| SCHEMBL7312695 | 0.86 | MALT1 (0.52) | MALT1CMA1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |