Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 11/20 | 0.53 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.53 |
| ▸ | REN | P00797 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 3/20 | 0.48 |
| ▸ | CTSG | P08311 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323606 | 0.92 | CMA1 (0.53) | CMA1MALT1ELANE | |
| SCHEMBL7285949 | 0.92 | CMA1 (0.53) | CMA1MALT1ELANE | |
| SCHEMBL7316337 | 0.92 | MALT1 (0.59) | CMA1MALT1RENACEELANE | |
| SCHEMBL7355181 | 0.89 | MALT1 (0.59) | CMA1MALT1RENELANE | |
| SCHEMBL7320470 | 0.87 | CMA1 (0.51) | CMA1MALT1RENACESLC6A2 | |
| SCHEMBL29642752 | 0.86 | ACE (0.66) | CMA1MALT1RENACEELANE | |
| SCHEMBL31632672 | 0.86 | ACE (0.66) | CMA1MALT1RENACEELANE | |
| SCHEMBL7313928 | 0.85 | CMA1 (0.55) | CMA1MALT1RENACESLC6A2 | |
| SCHEMBL29642770 | 0.85 | ACE (0.56) | CMA1MALT1RENACESLC6A2 | |
| SCHEMBL22424852 | 0.85 | SLC6A2 (0.59) | CMA1MALT1RENACESLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |