Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.53 |
| ▸ | ECE1 | P42892 | 2/20 | 0.53 |
| ▸ | ACE | P12821 | 2/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10790828 | 0.99 | MME (0.52) | MMEECE1ACEHRH4CYP3A4 | |
| SCHEMBL7365444 | 0.90 | MME (0.50) | MMEECE1ACEHRH4CYP3A4 | |
| SCHEMBL7369951 | 0.88 | EPHX2 (0.49) | MMEECE1HRH4CYP3A4CYP2D6 | |
| SCHEMBL7365124 | 0.85 | MME (0.48) | MMEECE1ACEHRH4CYP3A4 | |
| SCHEMBL7362104 | 0.85 | PPARG (0.53) | MMEECE1EPHX2PPARG | |
| SCHEMBL7368050 | 0.85 | MME (0.50) | MMEECE1ACEHRH4 | |
| SCHEMBL10790695 | 0.85 | MME (0.50) | MMEECE1ACEHRH4 | |
| SCHEMBL10790277 | 0.85 | MME (0.46) | MMEECE1ACEHRH4CYP3A4 | |
| SCHEMBL10792960 | 0.85 | LTA4H (0.46) | MMEECE1ACEHRH4CYP3A4 | |
| SCHEMBL10789536 | 0.84 | MME (0.49) | MMEECE1ACEHRH4MMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4749688-A | Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-06-07 | — | — | US | claimed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | claimed |
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | claimed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | claimed |
| EP-0566157-A1 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1993-10-20 | — | — | EP | disclosed |
| EP-0117429-B1 | PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES | SCHERING CORPORATION (US) | 1987-09-02 | — | — | EP | disclosed |
| EP-0117429-A1 | Phosphorous containing compounds as inhibitors of enkephalinases | SCHERING CORPORATION (US) | 1984-09-05 | — | — | EP | disclosed |