Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.56 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | CTSH | P09668 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316514 | 1.00 | REN (0.56) | RENMMP8CTSLCTSBCTSH | |
| SCHEMBL9442920 | 0.96 | REN (0.53) | RENMMP8CTSLCTSBCTSH | |
| SCHEMBL9442915 | 0.96 | REN (0.53) | RENMMP8CTSLCTSBCTSH | |
| SCHEMBL7316236 | 0.85 | REN (0.54) | RENMMP8CTSS | |
| SCHEMBL7316243 | 0.85 | REN (0.54) | RENMMP8CTSS | |
| SCHEMBL9442912 | 0.85 | REN (0.59) | REN | |
| SCHEMBL7328676 | 0.81 | REN (0.62) | REN | |
| SCHEMBL7323062 | 0.81 | REN (0.62) | REN | |
| SCHEMBL9833483 | 0.81 | REN (0.62) | REN | |
| SCHEMBL9442943 | 0.79 | REN (0.57) | RENMMP8CTSLCTSBCTSH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5268374-A | Containing both amide and hydroxy groups | ABBOTT LABORATORIES (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| EP-0364804-A1 | Non-peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-04-25 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |