Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 6/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5381741 | 0.81 | ADRB2 (0.71) | ADRB2ADRB1ADRB3LMNAMEN1 | |
| SCHEMBL7318214 | 0.81 | ADRB2 (0.51) | ADRB2ADRB1ADRB3LMNAMEN1 | |
| SCHEMBL7313195 | 0.80 | AR (0.43) | ADRB2ADRB1ADRB3LMNAMEN1 | |
| SCHEMBL7310711 | 0.80 | ADRB2 (0.47) | ADRB2ADRB1ADRB3LMNAMEN1 | |
| SCHEMBL7313076 | 0.78 | CYP2D6 (0.47) | ADRB2ADRB1ADRB3LMNAMEN1 | |
| SCHEMBL7314970 | 0.75 | KMT2A (0.64) | ADRB2ADRB1KMT2AADRA1A | |
| SCHEMBL14484198 | 0.73 | MEN1 (0.46) | ADRB2ADRB1ADRB3LMNAMEN1 | |
| SCHEMBL7090393 | 0.72 | AR (0.64) | LMNAMEN1MAPK1KMT2AAR | |
| SCHEMBL24948597 | 0.72 | AR (0.56) | ADRB2ADRB1ADRB3LMNAMEN1 | |
| SCHEMBL7305982 | 0.72 | AR (0.47) | ADRB2ADRB1ADRB3LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258062-A | ISOPRENALINE ANTAGONISTS EFFECTING HEART RATE AND BLOOD PRESSURE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-03-24 | — | — | US | disclosed |
| US-4171370-A | Phenoxy-amino-propanols | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-10-16 | — | — | US | disclosed |