Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TKT | P29401 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323862 | 0.88 | GAA (0.45) | GAAPOLBTKTBRD4MAPT | |
| SCHEMBL7320150 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL11445607 | 0.80 | GAA (0.41) | GAAPOLBBRD4LMNANPC1 | |
| Hydrochloric Acid SCHEMBL6557329 | 0.74 | GAA (0.40) | GAAPOLBMAPTMAPK1ALPL | |
| SCHEMBL4931757 | 0.72 | MAPK1 (0.50) | GAAPOLBMAPTMAPK1TSHR | |
| SCHEMBL27614783 | 0.71 | SMN1; SMN2 (0.35) | POLBMAPTALPLTSHRHTT | |
| SCHEMBL21585140 | 0.70 | PDE4D (0.50) | GAAPOLBMAPTMAPK1LMNA | |
| SCHEMBL13516628 | 0.70 | MAPK1 (0.37) | GAAPOLBBRD4MAPTMAPK1 | |
| SCHEMBL17500332 | 0.69 | MAPT (0.41) | GAAMAPTMAPK1TSHRLMNA | |
| SCHEMBL23384516 | 0.68 | HCAR2 (0.35) | MAPTMAPK1ALPLHTTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-A1 | New pharmacologically active pyrazolopyridines | GRUPPO LEPETIT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |