Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 15/20 | 0.83 |
| ▸ | MMP9 | P14780 | 12/20 | 0.83 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.83 |
| ▸ | MMP1 | P03956 | 10/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TSPO | P30536 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.51 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.51 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316679 | 0.91 | MMP13 (1.00) | MMP13MMP9ADAM17MMP1TDP1 | |
| SCHEMBL7316136 | 0.91 | MMP13 (0.79) | MMP13MMP9ADAM17MMP1TDP1 | |
| SCHEMBL7324943 | 0.90 | MMP13 (0.84) | MMP13MMP9ADAM17MMP1TDP1 | |
| SCHEMBL7322655 | 0.89 | MMP13 (0.83) | MMP13MMP9ADAM17MMP1 | |
| SCHEMBL6814341 | 0.88 | MMP13 (0.65) | MMP13MMP9ADAM17MMP1TDP1 | |
| SCHEMBL6811198 | 0.87 | MMP13 (0.65) | MMP13MMP9ADAM17MMP1TDP1 | |
| SCHEMBL7316882 | 0.85 | MMP13 (0.63) | MMP13MMP9ADAM17MMP1TDP1 | |
| SCHEMBL7310743 | 0.84 | MMP13 (0.94) | MMP13MMP9ADAM17MMP1TDP1 | |
| SCHEMBL7317442 | 0.83 | MMP13 (1.00) | MMP13MMP9ADAM17MMP1TDP1 | |
| SCHEMBL7316120 | 0.82 | MMP13 (0.72) | MMP13MMP9ADAM17MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |