Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4153276 | 0.81 | MEN1 (0.53) | MEN1KMT2AOPRD1USP2CYP2C9 | |
| SCHEMBL4153281 | 0.81 | MEN1 (0.53) | MEN1KMT2AOPRD1USP2CYP2C9 | |
| SCHEMBL9530935 | 0.80 | MEN1 (0.51) | MEN1KMT2AOPRD1USP2CYP2C9 | |
| SCHEMBL5623535 | 0.80 | MEN1 (0.51) | MEN1KMT2AOPRD1USP2CYP2C9 | |
| SCHEMBL3919530 | 0.79 | MEN1 (0.50) | MEN1KMT2AOPRD1USP2CYP2C9 | |
| SCHEMBL27994808 | 0.79 | MEN1 (0.50) | MEN1KMT2AOPRD1USP2CYP2C9 | |
| SCHEMBL8051571 | 0.76 | MEN1 (0.47) | MEN1KMT2AOPRD1USP2CYP2C9 | |
| SCHEMBL27402701 | 0.76 | MEN1 (0.51) | MEN1KMT2AOPRD1USP2CYP2C9 | |
| SCHEMBL27664880 | 0.75 | MEN1 (0.42) | MEN1KMT2AOPRD1CYP2D6SLC6A2 | |
| SCHEMBL5633854 | 0.74 | OPRD1 (0.50) | MEN1KMT2AOPRD1OPRM1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159566-A1 | Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient | KANEBO, LTD. (JP) | 1985-10-30 | — | — | EP | claimed |
| US-4663325-A | 1-(2,3,4-tri-methoxybenzyl)-4[bis(4-fluorophenyl)methyl] piperazines are useful for treating cerebrovascular disease | KANEBO LTD. (JP) | 1987-05-05 | — | — | US | disclosed |
| US-4663325-A | 1-(2,3,4-tri-methoxybenzyl)-4[bis(4-fluorophenyl)methyl] piperazines are useful for treating cerebrovascular disease | KANEBO LTD. (JP) | 1987-05-05 | — | — | US | disclosed |
| EP-0159566-A1 | Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient | KANEBO, LTD. (JP) | 1985-10-30 | — | — | EP | disclosed |
| EP-0159566-A1 | Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient | KANEBO, LTD. (JP) | 1985-10-30 | — | — | EP | disclosed |