Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.45 |
| ▸ | OGT | O15294 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309600 | 0.90 | KCNH2 (0.53) | KCNH2NR3C1PGRSLC6A4PDE3B | |
| SCHEMBL7325908 | 0.90 | KCNH2 (0.47) | KCNH2NR3C1PGRSLC6A4PDE3B | |
| Hydrochloric Acid SCHEMBL7318449 | 0.89 | CRBN (0.51) | KCNH2NR3C1PGRSLC6A4PDE3B | |
| Hydrochloric Acid SCHEMBL7314392 | 0.89 | KCNH2 (0.52) | KCNH2NR3C1PGRSLC6A4PDE3B | |
| SCHEMBL7325917 | 0.85 | KCNH2 (0.46) | KCNH2NR3C1PGRSLC6A4PDE3B | |
| Hydrochloric Acid SCHEMBL7326137 | 0.85 | HTR2A (0.50) | KCNH2NR3C1PGRSLC6A4PDE3B | |
| SCHEMBL11044555 | 0.84 | KCNH2 (0.60) | KCNH2NR3C1PGRSLC6A4PDE3B | |
| SCHEMBL11044792 | 0.84 | NR3C1 (0.52) | KCNH2NR3C1PGRSLC6A4PDE3B | |
| Hydrochloric Acid SCHEMBL11039319 | 0.84 | NR3C1 (0.53) | KCNH2NR3C1PGRSLC6A4PDE3B | |
| SCHEMBL10835956 | 0.81 | KCNH2 (0.50) | KCNH2SLC6A4OGTHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845100-A | WITH HYPOTENSIVE AND ANTIINFLAMMATORY ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-04 | — | — | US | claimed |
| EP-0202760-A2 | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-26 | — | — | EP | claimed |