Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317640 | 0.94 | MAPK8 (0.75) | MAPK8KMT2APTGER4LMNAHPGD | |
| SCHEMBL7168843 | 0.92 | MAPK8 (0.72) | MAPK8KMT2APTGER4 | |
| Hydrochloric Acid SCHEMBL6904217 | 0.90 | MAPK8 (0.66) | MAPK8KMT2APTGER4LMNAHPGD | |
| SCHEMBL7371983 | 0.90 | MAPK8 (0.69) | MAPK8KMT2APTGER4LMNAHPGD | |
| SCHEMBL7371446 | 0.89 | LMNA (0.72) | MAPK8KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL4087178 | 0.88 | MAPK8 (0.69) | MAPK8KMT2APTGER4LMNAHPGD | |
| SCHEMBL7371159 | 0.87 | MAPK8 (0.62) | MAPK8KMT2APTGER4LMNAHPGD | |
| SCHEMBL7368852 | 0.87 | MAPK8 (0.65) | MAPK8PTGER4LMNAHPGDSMN1; SMN2 | |
| SCHEMBL7365751 | 0.86 | MAPK8 (0.67) | MAPK8KMT2APTGER4 | |
| SCHEMBL5373827 | 0.86 | MAPK8 (0.64) | MAPK8KMT2APTGER4LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| CN-1254335-A | Nicotinamide derivatives | PFIZER PROD INC (US) | 2000-05-24 | — | — | CN | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |