Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.50 |
| ▸ | PREP | P48147 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304859 | 0.89 | ACE (0.50) | ACEPREPLTA4HFKBP1A | |
| SCHEMBL7310434 | 0.79 | ACE (0.59) | ACEACE2LTA4H | |
| SCHEMBL474742 | 0.78 | ACE (0.60) | ACEACE2LTA4H | |
| SCHEMBL474618 | 0.78 | ACE (0.60) | ACEACE2LTA4H | |
| SCHEMBL29589468 | 0.78 | ACE (0.71) | ACEACE2LTA4H | |
| SCHEMBL6438881 | 0.78 | DPP4 (0.69) | ACEACE2LTA4H | |
| SCHEMBL22209470 | 0.78 | PREP (0.69) | ACEACE2PREP | |
| SCHEMBL22811348 | 0.78 | PREP (0.69) | ACEACE2PREP | |
| SCHEMBL7423200 | 0.78 | DPP4 (0.69) | ACEACE2LTA4H | |
| SCHEMBL6782785 | 0.78 | DPP4 (0.69) | ACEACE2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |