Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310243 | 0.91 | KLK5 (0.49) | ACELMNAACE2SMN1; SMN2 | |
| SCHEMBL10404674 | 0.84 | ACE (0.61) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL10058307 | 0.84 | ACE (0.61) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL10656580 | 0.81 | ACE (0.57) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL10887597 | 0.80 | ACE (0.56) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL9814474 | 0.80 | ACE (0.67) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL6438293 | 0.79 | ACE (0.65) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL6436560 | 0.79 | ACE (0.65) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL6436563 | 0.79 | ACE (0.65) | ACELMNAACE2LTA4HSMN1; SMN2 | |
| SCHEMBL6438290 | 0.79 | ACE (0.65) | ACELMNAACE2LTA4HSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |