Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8688876 | 0.85 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL8770460 | 0.81 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7387861 | 0.81 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| Hydrochloric Acid SCHEMBL7385711 | 0.80 | PDE4A (0.45) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| Hydrochloric Acid SCHEMBL7385714 | 0.80 | PDE4A (0.45) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL7995009 | 0.79 | PDE4B (0.52) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7765508 | 0.79 | PDE4B (0.52) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7914451 | 0.79 | PDE4B (0.52) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7320173 | 0.77 | PDE4A (0.44) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7320846 | 0.77 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CSLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962483-A | ANTIASTHMA AGENTS; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS, LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5962492-A | ANTIASTHMA AGENTS; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5739144-A | INHIBITORS OF PHOSPHODIESTERASE ENZYMES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |
| US-5723460-A | Cyclo (alkyl and alkenyl) phenyl-alkenylyl heteroaryl compounds and pharmaceutical compositions containing same | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-03-03 | — | — | US | disclosed |