Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320846 | 0.86 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7319546 | 0.85 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7322573 | 0.83 | PDE4A (0.43) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8688876 | 0.83 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6508090 | 0.82 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7309852 | 0.82 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7907983 | 0.80 | PDE4A (0.50) | PDE4APDE4DPDE4BPDE4CPDE5A | |
| SCHEMBL7915910 | 0.79 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7317902 | 0.77 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6585192 | 0.77 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |
| EP-0475444-B1 | Use of 4-fluoro-pyrimidine derivatives as components for ferroelectric liquid crystal mixtures and process to prepare these compounds | HOECHST AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0626957-B1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 1999-03-03 | — | — | EP | disclosed |
| US-5622977-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5580888-A | Styryl derivatives as anti-inflammatory agents | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |