Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 19/20 | 0.71 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.57 |
| ▸ | MASP2 | O00187 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671130 | 1.00 | F2 (0.71) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7017912 | 0.84 | F2 (0.69) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7021845 | 0.80 | F2 (0.81) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7019506 | 0.74 | F2 (0.55) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7024780 | 0.73 | F2 (0.62) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7019802 | 0.73 | F2 (0.63) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7021980 | 0.72 | F2 (0.62) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7025567 | 0.72 | F2 (0.62) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7992846 | 0.71 | F2 (0.60) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7021036 | 0.71 | F2 (0.60) | F2PRSS1PRSS2PRSS3MASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180627-B1 | INDOLE, INDAZOLE, BENZOTRIAZOLE AND BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2001-01-30 | — | — | US | claimed |
| US-6417203-B1 | HETEROCYCLIC AMIDES | PFIZER INC. | 2002-07-09 | — | — | US | disclosed |
| US-6180627-B1 | INDOLE, INDAZOLE, BENZOTRIAZOLE AND BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2001-01-30 | — | — | US | disclosed |
| EP-0997474-A1 | Antithrombotic agents | PFIZER INC. (US) | 2000-05-03 | — | — | EP | disclosed |