SCHEMBL7318656

SCHEMBL7318656

Cc1nc2n(c(=O)c1CCO)CCCS2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.51
MAPT P10636 6/20 0.44
ADORA3 P0DMS8 1/20 0.44
XDH P47989 1/20 0.44
LMNA P02545 1/20 0.44
KMT2A Q03164 3/20 0.43
HPGD P15428 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
MEN1 O00255 1/20 0.43
RECQL P46063 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
KDM4E B2RXH2 2/20 0.43
NPC1 O15118 1/20 0.43
GLA P06280 1/20 0.43
RAB9A P51151 1/20 0.43
ATM Q13315 1/20 0.42
POLB P06746 1/20 0.42
HSD17B10 Q99714 1/20 0.42
MAPK1 P28482 1/20 0.41
CYP2C9 P11712 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3785984 0.92 GAA (0.47) ALDH1A1MAPTXDHLMNAKMT2A
SCHEMBL8804527 0.87 ALDH1A1 (0.52) ALDH1A1MAPTADORA3XDHLMNA
SCHEMBL7318796 0.86 ALDH1A1 (0.51) ALDH1A1MAPTADORA3XDHLMNA
Bromide SCHEMBL9747692 0.85 ALDH1A1 (0.50) ALDH1A1MAPTADORA3XDHLMNA
SCHEMBL10924999 0.78 CYP2C19 (0.45) ALDH1A1MAPTXDHLMNAKMT2A
SCHEMBL10922397 0.77 CYP2C19 (0.44) ALDH1A1MAPTXDHLMNAKMT2A
Hydrochloric Acid SCHEMBL7291893 0.76 CYP2C19 (0.43) ALDH1A1MAPTXDHLMNAKMT2A
Bromide SCHEMBL7142006 0.76 CYP2C19 (0.43) ALDH1A1MAPTXDHLMNAKMT2A
SCHEMBL5623016 0.74 DRD2 (0.48) ALDH1A1MAPTKMT2ASMN1; SMN2MEN1
SCHEMBL12943501 0.74 DRD2 (0.53) ALDH1A1HPGDKDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5126339-A Antihistamine, antiserotonine JANSSEN PHARMACEUTICA N.V. (BE) 1992-06-30 US disclosed
US-5025014-A Antiallergens JANSSEN PHARMACEUTICA N.V. (BE) 1991-06-18 US disclosed
US-4888426-A CHEMICAL INTERMEDIATES JANSSEN PHARMACEUTICA N.V. (BE) 1989-12-19 US disclosed
US-4804663-A PSYCHOLOGICAL DISORDERS JANSSEN PHARMACEUTICA N.V. (BE) 1989-02-14 US disclosed
EP-0110435-B1 NOVEL ((BIS(ARYL)METHYLENE)-1-PIPERIDINYL)ALKYL-PYRIMIDINONES JANSSEN PHARMACEUTICA N.V. (BE) 1989-01-04 EP disclosed
US-4695569-A ANTIALLERGENS JANSSEN PHARMACEUTICA N.V. (BE) 1987-09-22 US disclosed
EP-0196132-A2 1,2-Benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1986-10-01 EP disclosed
EP-0070053-B1 NOVEL BICYCLIC PYRIMIDIN-5-ONE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1986-04-16 EP disclosed
US-4581171-A ANTISEROTONINE AGENTS JANSSEN PHARMACEUTICA, N.V. (BE) 1986-04-08 US disclosed
US-4548938-A PSYCHOTROPIC AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 1985-10-22 US disclosed
US-4533665-A SEROTONIN ANTAGONIST JANSSEN PHARMACEUTICA (BE) 1985-08-06 US disclosed
US-4529727-A Pyrimido[2,1-b][1,3]-thiazines JANSSEN PHARMACEUTICAL, N.V. (BE) 1985-07-16 US disclosed
EP-0144101-A2 Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines JANSSEN PHARMACEUTICA N.V. (BE) 1985-06-12 EP disclosed
US-4485107-A SEDATIVES, MUSCLE RELAXANTS JANSSEN PHARMACEUTICA N.V. (BE) 1984-11-27 US disclosed
EP-0110435-A1 Novel ((bis(aryl)methylene)-1-piperidinyl)alkyl-pyrimidinones JANSSEN PHARMACEUTICA N.V. (BE) 1984-06-13 EP disclosed
US-4443451-A PSYCHOTROPIC, ANTIHISTAMINES, ANTISEROTONINE JANSSEN PHARMACEUTICA N.V. (BE) 1984-04-17 US disclosed
EP-0070053-A2 Novel bicyclic pyrimidin-5-one derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1983-01-19 EP disclosed