Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 14/20 | 0.72 |
| ▸ | PLG | P00747 | 7/20 | 0.72 |
| ▸ | F2 | P00734 | 6/20 | 0.72 |
| ▸ | PLAT | P00750 | 6/20 | 0.72 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.72 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.72 |
| ▸ | KLK1 | P06870 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | F9 | P00740 | 2/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | CFD | P00746 | 1/20 | 0.46 |
| ▸ | C1S | P09871 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320326 | 0.87 | PLAU (0.59) | PLAUPLGF2PLATPRSS1 | |
| SCHEMBL7341931 | 0.84 | PLAU (1.00) | PLAUPLGF2PLATPRSS1 | |
| SCHEMBL7320266 | 0.83 | PLAU (0.65) | PLAUPLGF2PLATPRSS1 | |
| SCHEMBL13709559 | 0.83 | HDAC1 (0.54) | PLAUPLGF2PLATPRSS1 | |
| SCHEMBL13709593 | 0.78 | NPC1 (0.57) | PLAUPLGPLATHDAC1NPC1 | |
| Hydrochloric Acid SCHEMBL7345059 | 0.76 | PLAU (0.74) | PLAUPLGF2PLATPRSS1 | |
| SCHEMBL13709595 | 0.76 | HDAC1 (0.74) | PLAUPLGF2PLATPRSS1 | |
| SCHEMBL13709608 | 0.76 | PLAU (0.61) | PLAUF2HDAC1F9F10 | |
| SCHEMBL7345163 | 0.75 | PLAU (1.00) | PLAUPLGF2PLATPRSS1 | |
| SCHEMBL13709655 | 0.74 | CA2 (0.56) | PLAUHDAC1F9F10CFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207701-B1 | AS ANTI-ANGIOGENIC, ANTI-ARTHRITIC, ANTI-INFLAMMATORY, ANTI-RETINOPATHIC, CONTRACEPTIVE AND TUMORISTATIC AGENTS | ABBOTT LABORATORIES | 2001-03-27 | — | — | US | disclosed |