Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1813541 | 0.86 | SLC6A4 (0.64) | SLC6A4ACACBSLC6A2SLC6A3LMNA | |
| SCHEMBL7323659 | 0.73 | POLB (0.67) | LMNAPOLB | |
| SCHEMBL29586308 | 0.72 | EPHX1 (0.36) | SLC6A4 | |
| SCHEMBL29022785 | 0.71 | SLC6A4 (0.66) | SLC6A4ACACBSLC6A2SIGMAR1 | |
| SCHEMBL7321423 | 0.71 | GRIN2B (0.51) | LMNAPOLBSIGMAR1 | |
| SCHEMBL12404706 | 0.70 | SLC6A4 (0.59) | SLC6A4ACACBPOLBSIGMAR1 | |
| SCHEMBL7316113 | 0.68 | TAAR1 (0.63) | SLC6A4ACACBSLC6A2SLC6A3SIGMAR1 | |
| SCHEMBL21286088 | 0.68 | TAAR1 (0.63) | SLC6A4ACACBSLC6A2SLC6A3SIGMAR1 | |
| SCHEMBL178533 | 0.68 | TAAR1 (0.63) | SLC6A4ACACBSLC6A2SLC6A3SIGMAR1 | |
| SCHEMBL8275616 | 0.67 | DRD2 (0.39) | MDM2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4886812-A | REGULATING DOPAMINE CONCENTRATION; PARKINSON DISEASE, HYPOTENSIVE AGENT, SCHIZOPHRENIA | DR. KARL THOMAE GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| US-4843086-A | HYPOTENSIVE AGENTS, SCHIZOPHRENIA, PARKINSON'S DISEASE | BOEHRINGER INGELHEIM KG (DE) | 1989-06-27 | — | — | US | disclosed |
| US-4731374-A | PARKINSON*S DISEASE | DR. KARL THOMAE GMBH (DE) | 1988-03-15 | — | — | US | disclosed |
| EP-0186087-A1 | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs | Dr. Karl Thomae GmbH (DE) | 1986-07-02 | — | — | EP | disclosed |