Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.64 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.47 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.39 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.36 |
| ▸ | AVPR1A known ✓ | P37288 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319012 | 0.86 | SLC6A4 (0.52) | SLC6A4SLC6A2SLC6A3POLBLMNA | |
| SCHEMBL29022785 | 0.81 | SLC6A4 (0.66) | SLC6A4SLC6A2ACACBSIGMAR1CHRM1 | |
| SCHEMBL12404706 | 0.76 | SLC6A4 (0.59) | SLC6A4POLBACACBSIGMAR1KMT2A | |
| Hydrochloric Acid SCHEMBL23524375 | 0.76 | TAAR1 (0.61) | SLC6A4SLC6A2SLC6A3ACACBSIGMAR1 | |
| SCHEMBL11162290 | 0.76 | SLC6A2 (0.55) | SLC6A4SLC6A2SLC6A3ACACBSIGMAR1 | |
| Hydrochloric Acid SCHEMBL7343144 | 0.74 | SLC6A2 (0.59) | SLC6A4SLC6A2SLC6A3ACACBSIGMAR1 | |
| SCHEMBL178533 | 0.74 | TAAR1 (0.63) | SLC6A4SLC6A2SLC6A3ACACBSIGMAR1 | |
| SCHEMBL21286088 | 0.74 | TAAR1 (0.63) | SLC6A4SLC6A2SLC6A3ACACBSIGMAR1 | |
| SCHEMBL7316113 | 0.74 | TAAR1 (0.63) | SLC6A4SLC6A2SLC6A3ACACBSIGMAR1 | |
| SCHEMBL25541899 | 0.72 | SLC6A4 (0.55) | SLC6A4ACACBSIGMAR1KMT2ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960350-B1 | NEW N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES | BAYER IP GMBH (DE) | 2015-08-19 | — | — | EP | disclosed |
| US-8314269-B2 | N-(1-methyl-2phenylethyl)benzamide derivatives | BAYER CROPSCIENCE AG (DE) | 2012-11-20 | — | — | US | disclosed |
| US-8148419-B2 | N-(1-alkyl-2-phenylethyl)-carboxamide derivatives and use thereof as fungicides | BAYER CROPSCIENCE AG (DE) | 2012-04-03 | — | — | US | disclosed |
| US-20110237678-A1 | N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2011-09-29 | — | — | US | disclosed |
| US-7951973-B2 | N-(1-methyl-2Phenylethyl)benzamide derivatives | BAYER CROPSCIENCE AG (DE) | 2011-05-31 | — | — | US | disclosed |
| EP-1960379-B1 | N-(1-ALKYL-2-PHENYLETHYL)-CARBOXAMIDE DERIVATIVES AND USE THEREOF AS FUNGICIDES | BAYER CROPSCIENCE SA (FR) | 2010-06-30 | — | — | EP | disclosed |
| US-20090258912-A1 | N-(1-Alkyl-2-Phenylethyl)-Carboxamide Derivatives and Use Thereof as Fungicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2009-10-15 | — | — | US | disclosed |
| US-20090156682-A1 | N-(1-Methyl-2Phenylethyl)Benzamide Derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2009-06-18 | — | — | US | disclosed |
| EP-1960379-A1 | N-(1-ALKYL-2-PHENYLETHYL)-CARBOXAMIDE DERIVATIVES AND USE THEREOF AS FUNGICIDES | Bayer CropScience S.A. (FR) | 2008-08-27 | — | — | EP | disclosed |
| EP-1960350-A1 | NEW N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2008-08-27 | — | — | EP | disclosed |
| EP-1792901-A1 | N-(1-ALKYL-2-PHENYLETHYL)-CARBOXAMIDE DERIVATIVES AND USE THEREOF AS FUNGICIDES | Bayer CropScience S.A. (FR) | 2007-06-06 | — | — | EP | disclosed |
| WO-2007060164-A1 | N-(1-ALKYL-2-PHENYLETHYL)-CARBOXAMIDE DERIVATIVES AND USE THEREOF AS FUNGICIDES | BAYER CROPSCIENCE SA (FR) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007060162-A1 | NEW N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258912-A1 | N-(1-Alkyl-2-Phenylethyl)-Carboxamide Derivatives and Use Thereof as Fungicides | CYP1A2, CYP51A1, CYP1A1 | SLC6A4 3392/4885SLC6A2 2143/4885SLC6A3 3289/4885 |
| US-20090156682-A1 | N-(1-Methyl-2Phenylethyl)Benzamide Derivatives | CYP51A1, CYP1A2, CYP1A1 | SLC6A4 3657/4885SLC6A2 3277/4885SLC6A3 4188/4885 |
| US-20110237678-A1 | N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES | CYP51A1, CYP1A2, CYP1A1 | SLC6A4 3595/4885SLC6A2 3298/4885SLC6A3 4184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.