Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25832110 | 0.98 | THRB (0.46) | MAOAMAOBTHRBTHRAALDH1A1 | |
| SCHEMBL10495730 | 0.86 | CA12 (0.47) | MAOAMAOBALDH1A1CHRNB2CHRNB4 | |
| SCHEMBL13790265 | 0.83 | THRB (0.48) | MAOAMAOBTHRBTHRASLC2A1 | |
| SCHEMBL11567371 | 0.82 | THRB (0.56) | MAOAMAOBTHRBTHRASLC2A1 | |
| SCHEMBL21575599 | 0.82 | THRB (0.56) | MAOAMAOBTHRBTHRASLC2A1 | |
| SCHEMBL11569857 | 0.82 | THRB (0.56) | MAOAMAOBTHRBTHRASLC2A1 | |
| SCHEMBL21575598 | 0.82 | THRB (0.56) | MAOAMAOBTHRBTHRASLC2A1 | |
| SCHEMBL15500410 | 0.81 | MAOA (0.44) | MAOAMAOBTHRBTHRAALDH1A1 | |
| SCHEMBL7319055 | 0.81 | MAOA (0.44) | MAOAMAOBTHRBTHRAALDH1A1 | |
| SCHEMBL11437314 | 0.80 | THRB (0.49) | MAOAMAOBTHRBTHRAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845100-A | WITH HYPOTENSIVE AND ANTIINFLAMMATORY ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-04 | — | — | US | disclosed |
| EP-0202760-A2 | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-26 | — | — | EP | disclosed |